Synthesis, characterization and ibuprofen release profile of alumina mesoporous/CNT nanocomposite

Document Type : Original Paper

Authors

1 Materials Science and Engineering Department, Semnan University, Semnan, Iran

2 Assistant Professor in Semnan University

3 Pasteur Institute of Iran, National Cell Bank of Iran, Tehran, Iran

10.22075/imcf.2025.9524

Abstract

Alumina/CNT porous composites was synthesized using isopropoxide aluminum as an alumina source, multi-wall carbon nanotube as reinforcement and Pluronic F127 as a polymeric template by sol gel method. Pores were produced after calcinations at 700˚C. One of the considered applications of these nanocomposites is for being used as a drug delivery system (DDS); so, ibuprofen was used as a model drug for investigating this application. In order to improve chemical interactions between drug and its career, surfaces of nanocomposite were modified using post-synthesis method by 3-aminopropyltriethoxysilane (APTES). To investigate cytotoxic effect of nanocomposite and clinical applicability, cell culture test (MTT assay) was used. Drug release tests were done in phosphate buffer saline (PBS). Physical and chemical properties of the synthesized materials were characterized by x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), energy dispersive spectroscopy (EDS) and field emission scanning electron microscopy. Tests of drug loading and release were done by UV-Vis spectroscopy. The results of cell culture tests confirmed non-cytotoxicity of synthesized nanocomposite. It was found that, with increasing content of carbon nanotubes in composite and functionalizing the particle surfaces, drug loading was increased. Also, drug release of functionalized composites was slower than that of the non-functionalized material.

Keywords

Innovations in Materials: Current & Future
Volume 2, Issue 1
January 2015

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